A Review on Hepatoprotective Activity of Siddha Herbal Formulation Athimathuram and Sangam Verpattai Mathirai
Author : Dr. AG Nagappan and Dr. P Bharathajothi
Abstract :
Liver disorders represent a significant global health concern, with chronic liver diseases (CLDs) contributing substantially to morbidity and mortality, particularly in countries like India. While conventional Western medicine often carries risks of adverse effects and accessibility issues, traditional systems like Siddha offer promising alternative therapeutic avenues. This review investigates the hepatoprotective activity of a traditional Siddha herbal formulation, Athimathuram and Sangam Verpattai Mathirai, documented in classical Siddha texts.
The study systematically evaluates scientific evidence supporting the liver-protective effects of its key ingredients: Glycyrrhiza glabra (Athimathuram) and Azima tetracantha (Sangam Verpattai). Our analysis delves into Siddha principles linking specific tastes (sweet and bitter) to balancing liver-related humors and examines the modern pharmacological actions of these herbs. Findings indicate that Glycyrrhiza glabra exhibits robust hepatoprotective properties against drug-induced and alcohol-induced liver injuries, viral hepatitis, cirrhosis, fibrosis, and hepatic cancers, primarily through antioxidant, anti-inflammatory, and antiviral mechanisms. Similarly, Azima tetracantha demonstrates significant protective effects against chemical-induced liver damage, iron overload, and possesses anticancer potential.
This compilation of scientific evidence highlights the therapeutic potential of Athimathuram and Sangam Verpattai Mathirai in managing various hepatic conditions. The review suggests this Siddha formulation warrants further pre-clinical and clinical exploration to establish its efficacy and provide an evidence-based alternative for liver disease management, contributing to the development of integrated healthcare solutions.
Keywords :
Hepatoprotective activity, Siddha medicine, Herbal formulation, Glycyrrhiza glabra, Azima tetracantha.
